Invasion of host cells by apicomplexan parasites such as Toxoplasma and Plasmodium spp requires the sequential secretion of the parasite apical organelles, the micronemes and the rhoptries.The claudin-like apicomplexan microneme protein (CLAMP) is a conserved protein that plays an essential role during invasion by Toxoplasma gondii tachyzoites and
BackgroundRecent epidemiological and experimental data Dresser suggest a negative influence of shortened or disturbed night sleep on glucose tolerance.Due to the high prevalence of sleep disorders this might be a major health issue.However, no comparative studies of carbohydrate metabolism have been conducted in clinical sleep disorders.Methodology
Besides noticeable progress in device therapy during the past decade, more recent advances in the management of chronic heart failure have led to exciting new pharmacological options.Among these, the combined angiotensin II receptor/neprilysin inhibitor (ARNI) valsartan/sacubitril has already proven highly effective in heart failure with reduced ej